Almitrine 对机械通气和自主呼吸肺心病患者心肺功能影响的比较研究

THE EFFECT OF ALMITRINE ON HEMODYNAMICS AND BLOOD GAS TENSION IN PATIENTS WITH CHRONIG COR PULMONALE DURING MECHANICAL VENTILATION AND SPONTANEONS BREATHING

5例机械通气和6例自主呼吸肺心病患者接受了 Almitrine 对心肺功能影响的研究。结果表明,服用150mg Almitrine 后,两组患者的气体交换均明显改善。动脉血氧分压升高、分流减少,自主呼吸患者还伴有动脉血二氧化碳分压明显降低,但同时伴有肺动脉压力升高和肺血管阻力增加,其中,自主呼吸患者的改变最明显。虽然机械通气患者肺动脉压升高的幅度较自主呼吸患者的小,但动静脉血氧含量差明显增加,而且5例中4例有混合静脉血氧分压降低,提示组织供氧受到了影响。

Five chronic cor pulmonale patients with mechanical ventilation and other 6 with spontaneous breathing were investigated during Almitrine therapy.The results show ed that the gas exchange in both groups was improved significantly after oral intake of 150 mg Almitrine.The significant increment of PaO_2,PAP and pulmonary vascular resis tance (PVR) and significant reduction of shunt were found in both groups.PaCO_2 in pa tients with spontaneous breathing was reduced significantly.Although the increase of PAP in patients with mechanical ventilation was lower than the increase in patients with spontaneou breathing,C(a-v)O_2 was increased,and the PvO_2 in 4 patients was reduced.It suggests that the oxygen supply of tissue was deteriorated.