耳针和六味地黄丸加味预防和治疗去势雌鼠骨质疏松的实验研究

Experimental Study on Prevention and Treatment of Osteoporosis in Ovariectomized Rats with Auri-cular Acupuncture and Modified Liuwei Dihuang Pill

目的 :探讨耳针和中药六味地黄丸加味对绝经后骨质疏松症的防治作用及其作用机理。方法 :取 6 6只SD雌性大鼠按体重随机分为 6组 :假手术组、模型组、耳针组、中药组、耳针十中药组、西药组。后 4组分别经耳针、六味地黄丸加味、耳针加中药联合应用以及雌二醇治疗 3个月 ,观察耳针及中药对去势雌鼠的影响。结论 :耳针、中药皆能提高去势雌鼠的BMC、BMD ,防治PMO。

Purpose To explore prevention and treatment acti ons of auricular acupuncture and modifie d Liuwei Dihuang Pill on postmenopaus al osteoporosis and their mechanisms.Methods Sixty-six female rats were randomly divi ded into six groups according to their b ody weight,pseudooperation group (POG),m odel group (MG),auricular acupuncture gr oup (G),Chinese herb group (CHG),auric ular acupuncture plus Chinese herb group (AHG) and estrogen group (EG).Except fo r the POG,all the groups were ovariectom ized.After the operation,G,CHG,AHG and EG were treated respectively with auric ular acupuncture,Liuwei Dihuang Pill (LWP),a uricular acupuncture combined with Liuw ei Dihuang Pill,and estradiol benzoas.T hree months later,the effects of auricul ar acupuncture and Liuwei Dihuang Pil l on the rats were observed.Results Both auricular acupuncture and LWP can promote BMC and B MD in ovariectomized rats,so as to preve nt and treat PMO.The mechanism may be in crease serum estrogen level,decrease ser um PTH level and raise CT level,inhibiti ng bone resorption,increasing bone refor mation and decreasing bone reabsorption and then adjusting imbalance of bone met abolism.