摘要
目的:观察39例航海人员中原发性高血压(EH)患者血浆肾上腺髓质紊[ADM(13～52)]浓度,探讨其在EH患者发病中的病理生理意义。方法:用特异性放免法测定血浆ADM(13～52)含量。结果:39例EH患者血浆ADM(13～52)水平为(30.67±1.37)ng/L,高于30例健康航海人员(18.98±1.10)ng/L(P<0.01)。随着高血压病期的加重而增加(P<0.01)。血浆ADM(13～52)水平与脉压差和血浆内皮素(ET-1)水平均呈正相关(r分别为0.553、0.567,均P<0.01)。结论:ADM(13～52)是一种舒血管肽,EH患者血浆ADM(13～52)水平增加可能是机体维持内环境稳态的一种代偿性保护机制。
Objective: To observe the pathophysiological significance and levels of plasma adrenomedullin [ADM (13-52)] in 39 nautical personnel with essential hypertension. Methods: The concentration of plasma ADM (13-52) was measured with special radioimmunoassay. Results: The plasma ADM (13-52) levels (30.67±1.37) ng/L in 39 nautical personnel with essential hypertension were significantly higher than those in normal nautical personnel (18.98± 1.10) ng/L (P<0.01), and was well increased with the clinical stages or severity of the disease (P<0.01). There was a positive correlation between plasma ADM (13-52) level, pulse pressure, and endothelin (ET) level (r = 0.553,0.567,P<0.01). Conclusion: ADM (13-52) is a kind of dilative peptide, the elevation of plasma ADM (13-52) in patients with essential hypertension may be part of compensatory mechanism to maintain the body stability.
出处
《天津医药》
CAS
北大核心
2001年第10期582-584,共3页
Tianjin Medical Journal
