慢性肝炎患者血清甘胆酸与其肝组织炎症病理分度的相关性研究

The Study on the Relationship between Serum CA and Liver Tissue Inflammation Activity in Chronic Hepatitis

目的:探讨慢性肝炎患者血清甘胆酸与其在肝组织炎症病理分度(G)的相关性。方法:随机选择50例慢性肝炎患者,抽静脉血检测其血清甘胆酸,并行肝组织活检、病理检查。结果:肝组织炎症活动度越高,血清甘胆酸升高愈明显,G_1与G_2、G_2与G_3、G_3与G_4之间比较,呈现显著性差异(P<0.05),G与血清CA两者关系密切。结论:血清甘胆酸是观察慢性肝炎患者肝组织炎症变化的较敏感而准确的指标。

Objective: To study the relationship between serum conjugated bile acids (CA) and liver tissue inflammation activity in chronic hepatitis. Methods: Serum CA and liver tissue inflammation activity were examined with pathological method in 50 patients with chronic hepatitis. Results: With the liver tissue inflammation activity elevated, the serum CA increased. The serum CA was significantly correlated with the liver inflammation activity (G) in chronic hepatitis B (P<0.05). Conclusion: Serum CA is a sensitive marker for liver tissue inflammation activity in patients with chronic hepatitis.