冠心病、高血压、高脂血症患者血清载脂蛋白B与A_1测定的临床意义

CLINICAL SIGNIFICANCE OF DETERMINATION OF SERUM APOLIPOPROTEIN B AND A_1 IN PATIENTS WITH CORONARY HEART DISEASE,HYPERTENSION AND HYPERLIPIDEMIA

本文对冠心病、高血压、高脂血症患者进行了血清载脂蛋白(apo)B、A_1及脂蛋白胆固醇的水平测定,并与健康人正常参考值((?)±SD)相比,apo-B 水平升高,apo-A_1水平下降,差异有显著性或极显著性(P<0.02～0.001);低密度脂蛋白胆固醇(LDL-C)值升高,差异有极显著性(P<0.01～0.001);高密度脂蛋白胆固醇(HDL-C)及其亚组分均降低。并发现 HDL-C 降低,大都伴有甘油三酯(TG)升高,尤其 TG>2.26mmol/L 的人群中将有80%伴有 HDL_2-C 的减少。

Serum apolipoprotein(apo)B and A_1 in patients with cornoary heart disease,hypertension or hyperlipidemia were determined,and the values were compared with thenormal values in healthy adults.There was significant or markedly significant differencein the increase of apo B and decrease of ape A_1(P<0.02 and 0.001),and the increaseof low density lipoprotein cholesterol(LDL-C)also showed marked significance.Bothhigh density lipoprotein cholesterol(HDL-C)and its subfraction were decreased.In mostcases,the low level of HDL—C was associated with increase of triglyceride(TG),and 80%of patients especially those with TG level exceeding 26mmol/L were accompanied bydecrease of HDL_2-C.