原发性肝癌患者介入治疗前后细胞免疫功能测定

A STUDY OF CELL IMMUNITY IN PATIENTS WITH PRIMARY LIVER CANCER BEFORE AND AFTER INTERVENTIONAL TREATMENT

本文介绍应用单克隆抗体荧光免疫法测定20例正常人和34例中晚期原发性肝癌介入治疗前后的淋巴细胞亚群(T_3、T_4、T_8、NK).结果发现治疗前患者淋巴细胞亚群(T_3、T_4、NK)均低于正常水平(P<0.001),介入治疗后 T_3、T_4、T_6细胞群变化不大(P>0.05),而 NK 细胞群在术后1个月显著下降(P<0.01)。作者认为化疗性栓塞同时辅以过继免疫治疗(如白细胞介素-2、α-干扰素等)可提高 NK 细胞活性,改善临床疗效。

Fluorescence immunoassay of monoclonal antibody was used to test lymphocyte subsets(T3,T4,T8,NK)in 20 normal persons and 34 patients with advanced primary livercancer before and after interventional treatment.It was demonstrated that lymphocyte sub-sets were below the normal level before treatment(P<0.001).After treatment,no signi-ficant change was found in T3,T4 and T8 cells(P>0.05),but NK cells declined remarkablyone month after the treatment.It is believed that chemotherapeutic embolization combinedwith adoptive chemoimmuno-therapy(such as interleukin-2,α-interferon)may improveclinical effects through enhancing the activity of natural killer cells.