吡喹酮对日本血吸虫病兔血清离子浓度的影响

The Ions Changes of Praziquantel on Schistosoma Japonicum Infective Rabbit Serum

目的 :探讨经吡喹酮 (praziquantel)治疗后 ,感染日本血吸虫家兔血清中Ca2 + 、Na+ 等浓度的变化的临床意义。方法 :感染日本血吸虫家兔 4周后 ,经吡喹酮治疗 ,检测治疗后不同时间血清中Ca2 + 、Na+ 、K+ 、Cl-浓度的变化。结果 :喂药后 2h血清Ca2 + 明显下降 ,2周后才有所恢复但仍低于正常的浓度 ;血清Na+ 也下降 ,2周后才基本恢复用药前的水平。结论 :对日本血吸虫感染家兔经吡喹酮治疗后 ,血清Ca2 + 和Na+ 浓度低于喂药前的对照组 ,可考虑适当补充Ca2 + 和Na+ 制剂 ,防止血清低Ca2 + 、Na+ 对机体的损害 。

Abstract: To evaluate the clinic effect praziquantel treatment on rabbit changes of serum Ca 2+ , Na +, K +, Cl concentration. Methods: The changes of serum Ca 2+ , Na +, K +, Cl appearde concentration after infection of Schistosoma Japonicum 4 weeks by praziquantel treatment on rabbit. Results: (1) The serum Ca 2+ decreased in rabbit after praziquantel treatment 2 hours and serum Ca 2+ decreased after 2 weeks; (2) The serum Na + and Cl no change. Conclusion: The result explanation before and after praziquantel treatment may give Ca 2+ drugs to infective Schistosoma Japonicum peoples.