3种溶剂对来氟米特离体皮肤渗透的影响

The effect of three solvents on the permeation of leflunomide in excised mouse skin

目的 :研究溶剂对来氟米特离体皮肤渗透的影响。方法 :采用改良Franz扩散池 ,以离体小鼠皮肤为渗透屏障 ,渗透速率为指标 ,HPLC法测定来氟米特浓度。结果 :乙醇对来氟米特皮肤渗透有一定的促进作用 ,丙二醇和低浓度 1,3 二甲基 2 咪唑啉酮 (DMI)对来氟米特的皮肤渗透影响不大。结论 :3种溶剂都可用于来氟米特皮肤局部用制剂。

OBJECTIVE To study the effect of solvents on the permeation of leflunomide in excised mouse skin. METHODS Modified Franz-diffusion cell adopted as apparatus for in vitro skin permeation, excised mouse skin as permeation barrier and permeability as index, the concentration of leflunomide in the samples was measured by HPLC. RESULTS Ethanol has enhancement effect on the permeability of leflunomide, propylene glycol and lower concentration DMI have little effect on the permeability of leflunomide. CONCLUSIONS These solvents can be used in the skin local preparations of leflunomide.