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TNF家族新成员BLyS和其受体TACI 被引量:2

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摘要 众所周知,肿瘤坏死因子(tumor necrosis factor,TNF)家族参与各种免疫和炎症反应的调控.1994年Smith等人发现TNF家族所有成员,除α-淋巴毒素外,都是II型膜蛋白.它们的生物学作用方式主要是通过细胞间接触,由膜结合形式的配体与其相应的受体结合;或者通过加工和排出可溶性配体,配体再和其受体结合的.另外,该家族的其他成员诸如CD27L,C D30L,OX40L,FasL和4-IBBL都有胞浆调控区,它们与受体结合后能进行信号传递[1 -5]
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2001年第12期679-681,共3页 Chinese Journal of Immunology
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参考文献6

  • 1Jun Z,J Immunol,2001年,1卷,6页
  • 2Wu Youmei,J Biol Chem,2000年,275卷,35478页
  • 3Xia X Z,J Exp Med,2000年,192卷,137页
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  • 5Mukhopadhyay A,J Biol Chem,1999年,274卷,15978页
  • 6Shu H B,J Leukoc Biol,1999年,65卷,680页

同被引文献11

  • 1张华勇,冯学兵,孙凌云.系统性红斑狼疮患者骨髓间质干细胞生物学特性及对造血支持的研究[J].中华风湿病学杂志,2006,10(6):331-334. 被引量:13
  • 2Wu YM,Bressette D,Carrell JA,et al.Tumor necrosis factor(TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS[J].JBC,2000,275(10):35478-35485.
  • 3Cachero TG,Schwartz IM,Qian F,et al.Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor familymember BAFF(B cell activating factor)[J].Biochemistry,2006,192(2): 137-143.
  • 4Hauer J,Puschner S,Ramakfishnan P,et al.TNF receptor(TNFR)-associated factor (TRAF) 3 serves as inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappa B pathway by TRAF-binding TNFRs[J]. Proc Natl Acad Sci USA,2005,102(10):2874-2879.
  • 5von Bulow GU,Bram RJ.NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily[J].Science,1997,278(3):138-141.
  • 6Xia XZ,Treanor J,Senaldi G,et al.TACI is a TRAF-interacting receptor forTAILL-1,a tumor necrosis factor family member involved in B cell regulation[J]J Exp Med,2000,192(2):137-143.
  • 7Bemardena Nardelli,Omella Belredere,Viktor Roechke,et al.Synthesis and release of Blymphocyte stimulator form myeloid cells [J].Blood, 2001,17(2):198-201.
  • 8Youpei Wu,Dana Bressette.TNF receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BlyS[J].The Journal of Biological Chemistry,2000,275(6):35478-35481.
  • 9Sakurai D.Kanno Y,Hase H,et al.TACI attenuates antibody production costimulated by BAFF-R and CD40[J].Eur J Immunol,2007,37(1):110- 118.
  • 10Seshasayee D,Valdez P,Yan M,et al.Loss of TACI causes fatal Lymphopro-liferation and autoimmunity,establishing TACI as an inhibitory BLyS receptor[J].Immunity,2003,18(2):279-288.

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