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表皮生长因子受体在尖锐湿疣皮损中的表达 被引量:3

Expression of epidermal growth factor receptor in condyloma accuminata
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摘要 为探讨表皮生长因子受体 (EGFR)在尖锐湿疣 (CA)细胞增殖中的调节作用,用免疫组化 SP法检测 EGFR在 56例尖锐湿疣与 30名正常皮肤中的表达。结果 EGFR在尖锐湿疣组织除角质层外的表皮全层细胞均有强表达,正常皮肤中 EGFR也有表达,但主要在基底层细胞表达。 EGFR在尖锐湿疣皮损颗粒层细胞和棘层细胞中的表达显著强于正常皮肤 (P< 0.01)。结果示尖锐湿疣皮损中 EGFR的表达增强可能与 HPV6/11型感染上皮细胞过度增殖的致病过程有关。 To investigate the regulation of epidermal growth factor receptor(EGFR) in condyloma accuminata(CA). The expression of EGFR in 56 cases with CA and 30 cases of controls were studied by immunohistochemical technique(SP). We observed that the EGFR expressed strongly on the membrane of all epithelial cells in CA lesions and mainly localized on the membrane of basal cells controls. Moreover, the expression of EGFR on basal cells and suprabasal prickle cells in CA lesions was significantly stronger than that in controls(P< 0.01). Our results suggested that increased expression of EGFR in CA is associated with the hyperplasia of CA.
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2001年第4期216-217,共2页 Journal of Clinical Dermatology
关键词 表皮生长因子受体 尖锐湿疣 人类乳头瘤病毒 EGFR CA 皮损 免疫组化SP法 Epidermal growth factor receptor Condyloma accuminata Human papillomavirus
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