Vogt-小柳-原田综合征漏误诊分析

Analysis of the misdiagnosis and missed diagnosis of Vogt-Koyanagi-Harada syndrome in China

目的 :分析我国 Vogt-小柳原田 (VKH)综合征临床诊断中存在的问题。方法 :对 1996年 1月～ 2 0 0 0年 12月于中山眼科中心葡萄膜炎专科就诊的、以往资料完整的 12 3例 VKH综合征患者的临床资料 ,特别是漏诊、误诊、发病至确诊时间和以往诊断等进行了分析。结果 :12 3例 VKH综合征患者的盲目发生率为 2 8.9%。在后葡萄膜炎期、前葡萄膜受累期和以前葡萄膜炎反复发作为特征的全葡萄膜炎期的漏诊、误诊率分别为 96 .7%、86 .2 %和 74.0 % ;眼部发病至确诊时间平均为 2 4.5个月。结论 :我国 VKH综合征患者的漏诊和误诊十分常见 。

Objective: To investigate the present status in the diagnosis of Vogt-Koyanagi-Harada (VKH) syndrome n China. Methods: Data of 123 patients with VKH syndrome, coming from all over the China and referred to Zhongshan Ophthalmic Center from January 1996 to December 2000, were retrospectively analyzed, especially with respects to the former misdiagnosis or missed diagnosis. Results: Blindness occurred in 28.9% of these investigated patients. Misdiagnosis or missed diagnosis occurred in 96.7%, 86.2% and 74.0% of these patients respectively in posterior uveitis stage, anterior uvea-involved stage and recurrent anterior uveitis stage. The average duration between uveitis onset and the time to make correct diagnosis was 24.5 months. Conclusions: The misdiagnosis of missed diagnosis of VKH syndrome is very common in China. It is absolutely necessary to popularize the knowledge about VKH syndrome among ophthalmologists in China.