大黄蒽醌类在大承气汤复方配伍中的量变规律研究

Study on the Quantitative Change of Anthraquinonoids of Rhei in the Preparation of Dachengqi

目的 :研究大承气汤传统煎法“先煎枳、朴 ,后下大黄 ,纳芒硝 ,溶化服”的科学内涵。方法 :高效液相色谱法测定各煎煮液中的游离和结合蒽醌类成分 (大黄素、大黄酸、大黄酚、芦荟大黄素 )。结果 :芒硝、厚朴、枳实与大黄配伍时 ,大黄各蒽醌类成分含量均发生规律性变化。结论 :大承气汤传统煎法的科学性就在于有效地提高了主要有效成分的溶存量 。

Objective:To study the scientific evidence of the traditional preparation of Dachengqi:'Boiling Aurantii Immaturus and Magnoliae Officinalis first, and then adding Rhei to decoct together. Discarding the dregs, adding Natrii Sulfas into the decoction and drinking the upper solution when the Natrii Sulfas has dissolved completely'.Method:The concentrations of free and combined anthraquinonoids(emodin, rhein, chrysophanol, physcion) in different decoctions were determined with HPLC method respectively.Result:When Natrii Sulfas, Aurantii Immaturus and Magnolias Officinalis are decocted with Rhei in different schemes, the concentrations of anthraquinonoids were changed regularly.Conclusion:The scientific evidence of traditional preparation method greatly increased the concentrations of the active components in Dachengqi.