补阳还五汤对心肌梗死后患者心脏重塑及心功能改善作用的临床研究

Clinical study on inproving effect with Buyang Huanwu decoction (BYHWD,补阳还五汤) on cardiac remodeling and heart function in patients after myocardial infarction

目的 :探讨补阳还五汤治疗心肌梗死的机制。方法 :将 5 6例患者随机分为治疗组 (36例 )和对照组(2 0例 ) ,2组患者常规治疗相同 ,治疗组加用补阳还五汤 ,每日 1剂。 2组均于 6个月后观察心脏重塑和心功能的变化。结果 :治疗组有效率 91.7% ,对照组有效率 6 5 .0 % ,治疗组疗效明显优于对照组 (χ2 =5 .6 7,P<0 .0 5 ) ;治疗组治疗后心脏重塑和心功能的指标与治疗前及对照组治疗后比较均有显著改善 (P<0 .0 5或 P<0 .0 1)。结论 :补阳还五汤对心肌梗死后患者具有阻止心脏重塑。

Objective:To explore the mechanisn of Buyang Huanwu decoction(BYHWD,补阳还五汤) intreating myocardial infarction.Methods:Fivtysix patients with myocardial infaction were randomly divided into treatment group ( n =36) and control group( n =20).The conventional therapy was the same in both groups,and the treatment group added to the BYHWD once a day.After six months the changes in the parameters of cardiac remodeling and heart function were observed.Results:The total effective rate in treatment group was 91 7%,and it was 65 0% in control group,so the curative effect in treatment group was significantly superior to that in control group (χ 2=5 67, P <0 05).The parameters of cardiac remodeling and heart function were significantly different not only after and before therapy in the treatment group but also after in the control group ( P <0 05 or P <0 01),Conclusions:BYHWD is able to improve the heart function and prevent cardiac remodeling in patients after myocardial infarction.