扶正解毒颗粒防治医院获得性肺炎的实验研究

Experimental study on preventive and therapeutic effects of Fuzheng Jiedu pellet (扶正解毒颗粒) on nosocomial pneumonia

目的 :观察扶正解毒颗粒防治医院获得性肺炎的作用机制。方法 :把实验动物随机分为扶正解毒颗粒大剂量组 ,扶正解毒颗粒小剂量组 ,人参归脾丸组和常水组 ,观察扶正解毒颗粒对大白鼠棉球肉芽肿和胸腔白细胞游走的影响及对小白鼠耳肿胀率及免疫功能的影响。结果 :扶正解毒颗粒大、小剂量组与常水组和人参归脾丸组比较 ,均可显著抑制大白鼠棉球肉芽肿增生及白细胞游走 (P<0 .0 5和 P<0 .0 1) ;与常水组比较能明显抑制小白鼠耳肿胀率及胸腺指数 (P<0 .0 5和 P<0 .0 1) ;与人参归脾丸组比较能明显抑制小白鼠耳肿胀率(P<0 .0 5 ) ;与人参归脾丸组和常水组比较均能明显提高吞噬活性 a(P<0 .0 5和 P<0 .0 1)。结论 :扶正解毒颗粒具有较好的抗炎、增强免疫功能的作用 。

Objective:To observe the effective mechanism of Fuzheng Jiedu pellet(扶正解毒颗粒) on preventing and treating nosocomial pneumonia.Methods:The experimental animals were randomly divided into large dosage group (LDG),small dosage group(SDG) of Fuzheng Jiedu pellet,Renshen Guipi pill group(人参归脾丸) ,and water group (WG).The influences of Fuzheng Jiedu pellet on granuloma induced by cotton ball and leukocyte migration of pectoral cavity in rats were observed,simultaneously the influences on swelling rate of ear and immunological function in mice.Results:In comparison with WG and Rensheng Guipi pill group the effects on inhibiting granuloma proliferation induced by cotton ball and leukocyte migration in LDG and SDG of Fuzheng Jiedu pellet were obviously significant ( P <0 05 or P <0 01).In comparison with WG,the swelling rate of ear and thymus index in mice were significantly inhibited ( P <0 05 or P <0 01),otherwise in comparison with Renshen Guipi pill group the swelling rate of ear was inhibited significantly too in LDG and SDG.Furthermore the phagocytosis activities in LDG and SDG were increased significantly if compared with WG and Renshen Guipi pill group ( P <0 05 or P <0 01).Conclusions:Fuzheng Jiedu pellet possesses beter anti inflammatory and increasing immunological function effects.It is able to prevent and treat nosocomial pneumonia effectively.