急性有机磷农药中毒患者血胆碱酯酶和肌酸磷酸激酶的变化与临床意义

Changes and clinical significances of serum cholinesterase and creatine phosphokinase in patients with acute organic phosphorus intoxication

目的 :探讨血胆碱酯酶 (Ch E)及血清肌酸磷酸激酶 (CPK)在急性有机磷农药中毒 (AOPI)时的变化特点及其临床意义。方法 :对 5 0例采用中西医结合方法治疗的 AOPI患者 ,根据中毒的程度分为轻度中毒组、中度中毒组和重度中毒组 ,并以 2 5例健康体检者作对照组。采用试纸法和速率法分别检验 Ch E和 CPK活性 ,并观察患者心脏功能改变。结果 :与健康对照组比较 ,AOPI患者血清 CPK均有不同程度升高 (P均 <0 .0 1) ,且与中毒程度呈平行关系。血 Ch E活性均有不同程度降低 ,下降程度有时与中毒程度不相平行。结论 :AOPI患者血清 CPK升高越显著 ,提示中毒程度越重 ,其预后不良 。

Objective:To investigate the changes and clinical significances of serum cholinesterase(ChE) and creatine phosphokinase(CPK) in patients with acute organic phosphorus intoxication(AOPI).Methods:According to the poisoning degree 50 cases who were treated with integrated traditional Chinese medicine and western medicine (TCMWM) were divided into mild intoxication group (MIG),moderate intoxication group and severe intoxication group (SIG),otherwise 25 healthy persons were selected as control group (CG).By means of test paper and speed the serum ChE and CPK were detected respectively,meanwhile the changes in cardiac functions were observed.Results:In comparison with healthy persons the levels of CPK in patients with AOPI were increased in various degree and the increased degree was parallel to intoxication degree.Otherwise the activities of ChE were decreased but the decreased degree was not parallel to.Conclusions:The more significant is the increase in serum CPK the more severe is the poisoning degree in patients with AOPI and the prognosis is harmful.It possesses important significance for confirming diagnosis.