摘要
目的 :研制、开发口腔速崩片。方法 :以崩解时限和溶出度为指标筛选确定处方和工艺。结果 :制得的口腔速崩片能在20s内完全崩解 ,5min的药物累积溶出度达到99 %。结论 :采用国内现有设备 。
OBJECTIVE:To prepare a rapid-disintegrated lozenge METHODS:The formula and technology were decided by taking the disintegrating time and dissolubility as standard RESULTS:The lozenge could completely disintegrate in 20s and the accumnlated dissolubility of the model drug was 99% after 5 minutes in phosphate buffer(pH=6 80) CONCLUSION:Using now available equipment,suitable excipients and workmanship can prepare a rapid-disintegrated lozenge
出处
《中国药房》
CAS
CSCD
2001年第11期657-658,共2页
China Pharmacy
基金
甘肃省科委资助项目 (QS-002-C33-016)
关键词
口腔速崩片
赋形剂
崩解时限
溶出度
rapid-disintegrated lozenge
excipient
disintegrating time
dissolubility
