142例头孢菌素肾损害分析

Review of Cephalosporins-induced Renal Damage

目的 :探讨头孢菌素类抗生素致肾脏不良反应的发生规律。方法 :以《中国药学文摘》1992年1月～2000年12月9年间发表的有关头孢菌素致肾损害文摘为线索 ,检索原刊文献 ,进行统计分析。结果 :142例肾损害涉及5种药品 ,分别为头孢拉定111例 ,头孢哌酮13例 ,头孢唑啉13例 ,头孢氨苄4例 ,头孢曲松1例。临床主要表现分别为血尿122例 ,肾功能衰竭7例 ,尿潴留6例 ,急性肾炎5例。结论

OBJECTIVE:To investigate the characteristics of emergence of renal damage induced by cephalosporins METH_ODS:Data of renal damage induced by cephalosporins were collected from published articles,which were retrieved from CHINESE PHARMACEUTICAL ABSTRACT issued between January 1992 and December 2000,and analysed RESULTS:There were 142 cases involving in renal damage induced by 5 kinds of cephalosporins;Cefradine(111),Cefoperazone(13),Cefazolin(13),Cefalexin(4),Ceftriaxone(1) The main clinical manifestations were hematuria(122),acute renal failure(7),urinary retention(6) and acute glomerulonephritis(5) CONCLUSION:Only when the cephalosporins are rationally used can ARDs be reduced