国产多沙唑嗪及特拉唑嗪对比治疗原发性高血压

Clinical comparison of the efficacy of doxazosin and terazosin in treatment of essential hypertension

目的 :评价国产多沙唑嗪 (doxazosin)治疗原发性高血压病的疗效及安全性。方法 :2 2 7例坐位舒张压(SeDBP)为 12 .6 7～ 15 .33kPa的原发性高血压患者 ,随机分为 2组 ,分别服用多沙唑嗪 2mg ,qd ;或特拉唑嗪 2mg ,qd。药后 2周末SeDBP≥ 12 .6 7kPa者 ,二药剂量分别加倍 ,继续服用 2周 ,治疗共 4周。以安慰剂期末 (药前 )及治疗后 2 ,4周测诊室血压、心率并记录症状、体征及实验室检查指标 ,评价其疗效和安全性。结果 :治疗 4周后多沙唑嗪组有效率 6 7.0 % (75 /112 ) ,特拉唑嗪组 6 3 .4% (6 4/10 1) ,2组比较无显著性差异 (P >0 .0 5 )。 2组坐位收缩压(SeSBP) /SeDBP均下降 ,血压下降幅度无显著性差异 (P >0 .0 5 )。多沙唑嗪组 5 9例加量至 4mg ,特拉唑嗪组 5 2例加量至 4mg。二药其他常见的不良反应相似 ,为头晕、头痛、心悸及乏力 ,多可耐受 ,继续用药后逐渐消失。 2组实验室检查未见有临床意义的变化。结论 :多沙唑嗪 2～ 4mg·d-1可以有效治疗原发性高血压 。

Objective:To evaluate the efficacy and safety of doxazosin in treatment of essential hypertension.Methods:227 patients with seated diastolic BP(SeDBP) of 12.67～15.33kPa were randomly divided to receive 2 mg once daily doxazosin or 2 mg terazosin once daily for 2 weeks.Patients with a SeDBP higher than 12.67kPa in the end of treatment were treated with double dose of doxazosin or terazosin for another 2 weeks.The patients baseline BP,heart rate,clinical safety,and specific symptoms at the end of the first and the second 2 weeks treatment and the efficacy and safety of doxazosin was evaluated by these parameters.Results:After 4 weeks treatment,there were no significant difference in effective rate of doxazosin(67.0%,75/112) and terazosin (63.4%,64/101),no significant difference in decrease range of SeSBP/SeDBP( P >0.05).The number of patients receiving a double dose were 59 for doxazosin and 52 for terazosin.The two drugs have similar adverse reaction such as dizziness,headache,palpitation and hypodynamia,and they were tolerable and disappeared in continuous treatment.Conclusion:Essential hypertension can be effectively treated with doxazosin in once daily dose of 2～4mg.