老年高血压患者伴陈旧性心肌、脑梗死后抗高血压因子活性的变化

The change in activity of antihypertensive factor in aged hypertensives with old myocardial or cerebral infarction

目的 观察老年高血压患者急性心肌梗死或脑梗死 1年后抗高血压因子 (AHF)活性的变化。方法 从正常血压老年人和老年高血压心肌梗死或脑梗死后患者的红细胞中提取出AHF ,以肾性高血压大鼠为模型行急性降压实验。结果 正常血压老年人或有高血压的老年患者红细胞中均含有AHF ;正常血压老年人及心肌梗死或脑梗死后未服降压药血压仍正常的老年原发性高血压患者AHF的综合活性指标 (对收缩压、舒张压、心率降低百分数的总和 )分别为 10 7.7、10 4.9和 99.0 ,三者差异无显著性意义 (P >0 .0 5 ) ,且均显著高于心肌梗死后 (5 7.2 )或脑梗死后血压仍高者 (5 4.8)的AHF活性 (P <0 .0 5 ) ;血压水平与其AHF的活性呈明显的负相关 (r为负值 ,│r│ >0 .6 3,P<0 .0 1) ,结论 老年高血压患者心肌梗死或脑梗死后血压的变化与其红细胞AHF活性的变化有关。

Objective To study the change in activity of antihypertensive factor(AHF) in the erythrocytes of senile essential hypertensives(SEH) with old myocardial infarction(OMI) or old cerebral infarction(OCI).Methods AHF was partially extracted from the erythrocytes of normotensive senile citizens (NSC) and senile essential hypertensives with OMI or OCI,and the acute antihypertensive experiment of AHF on the model of renal hypertensive rat(RHR) was carried out.Results AHF was present in the erythrocytes of both NSC and SEH with OMI or OCI.The integrated activity index of AHF from NSC and SEH with OMI or OCI who had normal blood pressure was 107.7,104.9 and 99.0 respectively,and there was no significant difference between them (P>0.05),but all of them were higher than that of AHF from SEH with OMI(52.2) or OCI(54.8) who had high blood pressure(P<0.05).No matter whether NSC or SEH with OMI or OCI who had normal or high blood pressure,the level of blood pressure was negatively correlated with the activity of AHF (r is negative,│r│>0.63,P<0.01).Conclusion The results suggest that the change of blood pressure in SEH with OMI or OCI is related to the change of activity of AHF from their erythrocytes.