粉防己碱对敌百虫中毒小鼠的保护作用

Protective Effect of Tetrandrine on Mice Poisoned with Trichlorfon

目的：验证粉防己碱对有机磷酸酯中毒动物的保护作用。方法：采用急性毒性试验，以判断粉防己碱对LD100剂量敌百虫中毒小鼠的保护作用。应用和未用粉防己碱处理的中毒小鼠死亡率间的差异显著性，以卡方测验进行检验。结果：粉防己碱（20～40 mg/kg，i.p.）对中毒小鼠有确切的保护效果，因为粉防己碱处理的动物死亡率明显低于用生理盐水处理的对照组死亡率（P＜0.05）；粉防己碱处理组的死亡率接近阿托品（10 mg/kg，i.p.）处理组的死亡率，二者之间无显著差异（P＞0.05）。结论：粉防己碱具有近似阿托品的对抗有机磷酸酯中毒功效，并提示它可被用作阿托品治疗此类毒物中毒时的协同剂。粉防己碱的作用机理目前尚不清楚，有待进一步探讨。

Acute toxicity experiment was done to determine the protective effect of tetrandrine on mice poisoned with trichlorfon (dipterex) of LD100.Significance in deviation of mortality between the poisoned mice treated with or without tetrandrine was examined by chisquare ( χ2 ) test.Results： Tetrandrine (20～40 mg/kg,i.p.) exhibited a definite protective effect on poisoned mice for the mortality of the animals treated with tetrandrine was significantly lower than that of the control group with normal saline ( P ＜0.05).The mortality in the group treated with tetrandrine was close to that in the group treated with atropine (10 mg/kg,i.p.) and there was no significant difference between them ( P ＞0.05).Conclusion： The results suggest that tetrandrine has protection against organophosphorus esters toxicity similar to that of atropine,and that it may be used as a synergist for atropine in the treatment of poisoning by these toxic compounds.The mechanism of action for tetrandrine is obscure at present and needs to be studied further.