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一种微生物来源的白细胞介素1受体拮抗剂——多糖139A的化学结构研究 被引量：2

STUDY ON THE STRUCTURAL PROPERTY OF POLYSACCHRIDES 139A A KIND OF IL-1R ANTAGONISTS FROM MICROORGANISM
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摘要 AIM To study the structural property of the bioactive component from the fermentation broth of Streptomyces 139 which can inhibit IL 1R. METHODS Polysaccharide 139A is extracted and purified by means of macroreticular resin Diaion HP 20, cation exchange and DEAE Sephadex A 25 chromatography. The sugar compositions were analyzed with GC, the linkage positions of 139A were determined by methylation and GC MS. RESULTS The bioactive component which can inhibit IL 1R is a kind of polysaccharides. CONCLUSION The components of 139A repeat units are conjectured. AIM To study the structural property of the bioactive component from the fermentation broth of Streptomyces 139 which can inhibit IL 1R. METHODS Polysaccharide 139A is extracted and purified by means of macroreticular resin Diaion HP 20, cation exchange and DEAE Sephadex A 25 chromatography. The sugar compositions were analyzed with GC, the linkage positions of 139A were determined by methylation and GC MS. RESULTS The bioactive component which can inhibit IL 1R is a kind of polysaccharides. CONCLUSION The components of 139A repeat units are conjectured.
作者 陈晶 吴剑波 刘叶民 徐桂芸
机构地区 中国医学科学院 中国科学院化学研究所
出处 《药学学报》 CAS CSCD 北大核心 2001年第10期787-789,共3页 Acta Pharmaceutica Sinica
基金 国家自然科学基金资助项目 ( 396 70 0 16 )
关键词 白细胞介素1 受体拮抗剂 多糖139A 化学结构 interleutin 1 receptor antagonist polysaccharide
分类号 R977.6 [医药卫生—药品]
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参考文献3

  • 1Wu Q，抗生素，1999年，24卷，6期，401页
  • 2Xu G Y，分析化学，1998年，26卷，8期，922页
  • 3Jansson P E，Chem Commun，1976年，8卷，15期，1页

同被引文献17

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药学学报
2001年 第10期

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