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工程抗体的体外成熟 被引量：3

In vitro maturation of engineered antibody
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摘要 工程抗体在诊断或治疗方面有其优点,但制备的各种工程抗体的亲和力通常较原亲本抗体的低。为方便在体外迅速地改善工程抗体的生物特性,目前已发展了一系列针对抗体库构建。 Thoughengineeredantibodyhasmanyadvangtagesindiagnosisor therapy,itsaffinityisusuallylowerthanthe parentantibody.Forrapidlyincreasingtheaffinityor specifityof engineeredantibody,manymethodsandtechnologiesthat involveintheconstructionandselectionof antibodylibraryandidentificationof bettermonoclonehavebeendeveloped.
作者 刘志刚 俞炜源
机构地区 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2002年第1期50-54,共5页 Letters in Biotechnology
关键词 工程抗体 抗体序 体外成熟 engineeredantibody antibodylibrary in vitro maturation
分类号 R392.2 [医药卫生—免疫学] R392－33 [医药卫生—免疫学]
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参考文献30

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共引文献4

同被引文献50

  • 1葛彦,张学光.人源化抗体研制策略分析及应用研究[J].国外医学（免疫学分册）,2004,27(5):271-274. 被引量：10
  • 2王宪文,毕英佐,曹永长,于康震.噬菌体肽库技术的应用[J].生物技术通讯,2004,15(5):489-491. 被引量：1
  • 3吴健敏,任兆钧,余兴龙,涂长春,张念祖.利用T4噬菌体展示猪瘟病毒E2抗原[J].中国生物工程杂志,2004,24(11):61-64. 被引量：3
  • 4陈士伟,郭建生,颜怀军,姚新生.双特异性抗体治疗卵巢癌的研究进展[J].中国实用妇科与产科杂志,2006,22(4):309-312. 被引量：3
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生物技术通讯
2002年 第1期

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