粒酶B与细胞凋亡

Granzyme B and apoptosis

粒酶 Ｂ（ＧｒＢ）是杀伤性 Ｔ淋巴细胞（ＣＴＬ）和自然杀伤细胞（ＮＫ）颗粒（granule)中最重要的丝氨酸蛋白酶；通过caspases依赖途径、直接入核途径及不依赖caspases的胞浆途径，启动ＣＴＬ介导的靶细胞凋亡。

Granzyme B is the most important serine protease in the granule of cytotoxic T lymphocytes and natural killer cells. The mechanism of granzyme B-induced apoptosis involves caspases-dependent pathway, directly nuclear entry and caspases-independent cytoplasmic path-ways.