游离和前列腺特异性抗原相互关系及临床应用

The Relativity of Free and Total Prostate Specific Antigen and it's Function in Clinic

目的 评价总前列腺特异性抗原 (tPSA)、游离前列腺特异性抗原 (fPSA)及百分率 (f/tPSA % )检测前列腺癌 (PCa)的相关性及临床价值。方法 用酶免法测定 35例PCa及 73例良性前列腺增生 (BPH)患者血清tPSA水平 ,4tPSA <10ng/ml患者另测其fPSA ,计算f/tPSA(% )。 结果 血清tPSA <4、4～ 10、>10ng/ml者发现PCa的比例组间相比均有统计学意义。 4～ 10ng/ml组 ,PCa和BPH者f/tPSA(% )分别是 9.1± 4.8、16 .4± 6 .1,差别有显著意义 (P <0 .0 1)。结论 tPSA仍是PCa筛查的有效瘤标 ,tPSA低水平时 ,f/tPSA(% )检测PCa则更为灵敏精确。

Objective To evaluate the total and free prostate specific antigen in detecting prostate cancer.Methods Serum total and free PSA were determined by Abbott IMX assay,f/tPSA(%) was calculated.Of the 108 patients,35 had PCa and 73 BPH.Results There was statistic difference of the incidence of PCa with tPSA<4ng/ml,4～10ng/ml,>10ng/ml.There also was statistic difference of f/tPSA(%) between PCa and BPH when 4<tPSA<10ng/ml.Conclusions T-PSA assay is important means to discover prostate carcinoma.When tPSA<10ng/ml,f/tPSA(%) is more sensitive and accurate.