腹腔注射异丙酚产生蓄积作用的实验研究

Accumulation Effects of Intraperitoneal Injection on the Hypnotic Potency of Propofol

目的 研究异丙酚腹腔重复注射的催眠效果。方法 昆明种小白鼠腹腔注射 (ip)生理盐水 0 .3ml/ 10g ,30min后 ,ip异丙酚 12 0mg/kg ,待各小鼠翻正反射恢复后 1h ,重复上述实验。 结果 翻正反射消失率首次给药为10 0 % ,二次给药为 90 .91% ,两者无明显差别。二次给药的起效时间及维持时间分别比首次给药延长 1.5min(P <0 .0 5 )及 38.7min(P <0 .0 5 )。结论 异丙酚腹腔重复注射后起效变慢 ,作用时间延长 ,产生明显蓄积作用。

Objective To examine the effects of repeated intraperitoneal injection on the hypnotic potency of propofol.Method Eleven Kunming mice,either male or female,received intraperitoneally (ip) propofol 120 mg/kg.1 hour later after the reappearing of righting reflex (RR),injecting propofol repeatedly but on the opposite side.The onset and duration of the loss of RR(LRR) following twice propofol injection were tested.Result There were no significant differances in the rate of LRR (100% vs 90.91%, P >0.05),but the onset of LRR (4.3±1.1min vs 5.8±1.9min, P <0.05) and the duration of LRR (49.2±23.5min vs 87.9±44.7min, P <0.05) were significantly longer after the second injection.Conclusion Repeated intraperitoneal injection can retard the beginning of propofol effect and prolong its hypnotic duration,showing an accumulation effect.