黄芪总皂苷抗血栓形成作用实验研究

Research on antithrombotic effect of total saponins of Astragalus

目的 :研究黄芪总皂苷 (TSA)抗血栓形成作用 ,探讨其作用机制。方法 :观察了TSA 5 0 ,10 0 ,2 0 0mg/kg 3种剂量组对于动脉血栓形成和血小板聚集的作用 ,并测定了药物对血栓素A2 (TXA2 )前列环素 (PGI2 )水平和一氧化氮 (NO)含量的影响。结果 :TSA具有显著抗实验性血栓形成作用 ,并能抑制血小板聚集 ,提高PGI2 和NO水平 ,降低TXA2 /PGI2 比例。结论 :TSA具有显著抗血栓形成作用 ,作用机制与提高PGI2

Objective: To research antithrombotic effect and mechanism of total saponins of Astragalus (TSA).Methods: Effects of TSA on artery thrombosis anud platelet aggregation were studied, at dosage of 50,100,200mg/kg. And level of TXA 2,PGI 2 in plasma, content of NO in serum of rats were determined.Results: TSA could restrain artery thrombosis and platelet aggregation of rats, and increase PGI 2 and NO.Conclusion: There was apparently antithrombotic effect of TSA.