摘要
采用复合因素的脾不统血证大鼠模型 ,以 6 酮 前列腺素F1α(6 酮 PGF1α)和血栓素B2(TXB2 )作为观测指标 ,对益气止血药对脾不统血证模型大鼠血浆和子宫前列腺素的影响进行了研究。结果 :大剂量组益气止血药能降低脾不统血证模型血浆和子宫的 6 酮 PGF1α及子宫 6 酮 PGF1α/TXB2 比值。说明 6 酮 PGF1α及 6 酮 PGF1α/TXB2 比值升高可能是脾不统血证的重要机理之一。
The effects of TCM drugs for benefiting qi and arresting bleeding (BQAB) on plasmatic and uterine prostaglandin were investigated in rats with TCM syndrome of spleen's failure to control the blood (SFCB) induced by complex factors, with 6 keto PGF 1α and thromboxane B 2 (TX B 2) as experimental criteria. The results showed that large dose of BQAB drugs could decrease plasmatic and uterine level of 6 keto PGF 1α and the ratio of 6 keto PGF 1α to TX B 2, which implies that the increase of both the level of 6 keto PGF 1α and the ratio of 6 keto PGF 1α to TX B 2 may be one of the important causes of SFCB syndrome.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2001年第6期31-33,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
高等学校博士基金课题
国家中医药管理局资助课题(No.2000-J-B-20)
关键词
益气止血
脾不统血证
前列腺素
动物实验
中药
Benefiting Qi and Arresting Bleeding
Syndrome of Spleen's Failure to Control the Blood
Prostaglandin
