α-synuclein与神经系统变性疾病
摘要
α -synuclein在神经组织中广泛存在 ,NACP是其人类同系物。α -synuclein基因的突变与家族性帕金森病(FPD)相关 ,而在PD的路易氏小体和Alzheimer病淀粉样斑块中也有大量的α -synuclein/NACP及其片断NAC存在。另外在其它神经系统变性疾病中也发现含α -synuclein的细胞内包涵体 ,提示不同原因引起的α
出处
《国外医学（神经病学．神经外科学分册）》
2001年第6期413-416,共4页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
参考文献21
-
1Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the αsyn gene identified in families with Parkinson's disease. Science, 1997,276(5321 ): 2045 - 2047.
-
2Kruger R, Kuhn W, Muller T, et al. Ala30Pro mutation in the gene encoding alpha- syn in Parkinson' s disease. Nat Genet, 1998, 18(2):106- 108.
-
3Feany MB, Bender WW. A drosophila model of Parkinson's disease.Nature, 2000, 404(6776): 394- 398.
-
4Arima K, Ueda K, Sunohara N, et al. Immunoelectron- microscopic demonstration of NACP/alpha - syn - epitopes on the filamentous component of Lewy bodies in Parkinson' s disease and in dementia with Lewy bodies. Brain Res, 1998, 808(1): 93-100.
-
5Crowther RA, Jakes R, Spillantini MG, et al. Synthetic filaments assembled from C - terminally truncated alpha - synuclein. FEBS Lett,1998, 436(3): 309 - 312.
-
6Takeda A, Mallory M, Sundsmo M, et al. Abnormal accumulation of NACP/α- syn in neurodegenerative disorders. Am J Pathol, 1998, 152(2): 367- 372.
-
7Souza JM, Giasson BI, Chen Q, et al. Dityrosine cross - linking promotes formation of stable alpha - syn polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synopathies. J Biol Chem, 2000, 275(24): 18344 - 18349.
-
8Hashimoto M, Takeda A, Hsu LJ, et al. Role of cytochrome c as a stimulator of alpha - syn aggregation in Lewy body disease. J Biol Chem, 1999, 274(41): 28849-28852.
-
9Paik SR, Shin HJ, Lee JH, et al. Copper ( Ⅱ ) - induced selfoligomerization of alpha - syn. Biochem J, 1999, 340(pt 3): 821 - 8.
-
10Takeda A, Hashimoto M, Mallory M, et al. C - terminal alphasynuclein immunoreactivity in structures other than Lewy bodies in nenrodegenerative disorders. Acta Neuropathol (Berl), 2000, 99( 3 ):296 - 304.
-
1范国华,刘振国,陈生弟.α-synuclein与帕金森病(综述)[J].中国神经免疫学和神经病学杂志,2001,8(2):105-108.
-
2李燕,余刚.载脂蛋白AI在帕金森病发病中的作用及临床价值[J].中风与神经疾病杂志,2015,32(6):573-574. 被引量：1
-
3陈琳.a-Synuclein蛋白与帕金森病[J].海军总医院学报,1999,12(4):217-220. 被引量：1
-
4陈涛,唐北沙,廖小平.α-突触核蛋白在帕金森病发病机制中的作用[J].中华神经科杂志,2006,39(6):415-418. 被引量：10
-
5周爱霞,周显青.α-synuclein在帕金森病中的研究进展[J].中国医学生物技术应用,2004(3):13-17.
-
6王俊,谢瑞满.铁代谢与帕金森病关系的研究进展[J].中国临床医学,2015,22(3):435-437. 被引量：1
-
7邹春林,孙异临,曲宝清,盛树力,赵志炜,段春礼.α-Synuclein与帕金森病临床前期动物模型研究[J].首都医科大学学报,2003,24(3):262-267. 被引量：1
-
8崔思松,俞正炎,吴衡,朱汉民,孟广勋,胡赓熙.阿尔茨海默病病人AACT、ERAB和NACP基因的多态性分析[J].中华医学杂志,2001,81(2):90-92. 被引量：1
-
9李梁蜜,方芳,曹文英,李承,冯裕星.阿尔茨海默病和血管性痴呆与血糖代谢水平的关系及危险因素分析[J].现代生物医学进展,2015,15(15):2932-2934. 被引量：11
-
10周霓.弥漫性路易氏小体病[J].国外医学（内科学分册）,1994,21(4):166-168.
