4Kamal A, Khanna GBK, Ramu R, et al.Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzedresolution of 3-hydroxy-3- (2-thienyl) propanenitrile [J].Tetrahedron Lett, 2003, 44 (25): 4783-4787.
5Liu H, Hoff BH, Anthonsen T.Chemo-enzymatic synthesis of the antidepressant duloxetine and its enantiomer [J].Chirality,2000, 12(1): 26-29.
6Wheeler WJ, Kuo F.An asymmetric synthesis of duloxetine hydrochloride, a mixed uptake inhibitor of serotonin and norepinephrine, and it C- 14 labelled isotopomers [J].JLabelled Compd Radiopharm, 1995; 36 (3): 213-223.
7Deeter J, Frazier J, Staten G, et al.Asymmetric synthesis and absolute stereochemistry of LY248686 [J].Tetrahedron Lett,1990, 36(3): 213-223.
8Berglund RA.Asymmetric synthesis of key intermediate in the synthesis of duloxetine via arylation of (S) - (-) -N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine with 1-fluoronaphthalene in presence of potassium compound [P].US:5362886, 1994-11-08.(CA 1994,
10Reichert D, Almena P, Juan J, et al.Preparation of N-methyl-3-hydroxy-3- (2-theneyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates [P].WO: 2003070720, 2003-08-28.(CA 2003, 139: 214324)
