邻苯二甲酸二丁酯(灭蚴宁)治疗蠕形螨病疗效观察

Effect of Dibutyl Phthalate on Demodicidosis

目的 观察灭蚴宁治疗蠕形螨病的效果及安全性。 方法 采用单盲、平行对照试验 ,将螨性痤疮81例和酒渣鼻 6 2例随机分成试验组和对照组 ,分别涂抹灭蚴宁和新肤螨灵 ,每天早、晚各 1次 ,连续 6 wk。 结果灭蚴宁对痤疮的基本控制率、显效率、好转率和总有效率分别为 5 3.7%、41.5 %、4.9%和 10 0 % ,与对照组有显著性差异 (P<0 .0 5 )。对酒渣鼻的基本控制率、显效率、好转率和总有效率分别为 40 .6 %、40 .6 %、18.8%和10 0 % ,与对照组无显著性差异 (P>0 .0 5 )。试验组未发生不良反应。 结论 灭蚴宁治疗蠕形螨病安全有效。

Objective To evaluate the curative effect and safety of dibutyl phthalate on demodicidosis. Methods A single blinded and controlled study of human demodicidosis treated with dibutyl phthalate was conducted. One hundred and forty three patients with demodicidosis, including 81 acne and 62 rosacea, randomly divided into trial and control groups. The trial group was treated with dibutyl phthalate and control group with 'new fumanling' cream twice a day in the early morning and evening respectively for six weeks consecutively. Results The rates of excellent, good, and fair efficacy and total effective rate in the trial group with acne were 53\^7%, 41\^5%, 4\^9% and 100% respectively, with a significant difference to the control group (P<0\^05). The rates in the trial group with rosacea were 40\^6%, 40\^6%, 18\^8% and 100% respectively, with no statistical difference to the control group (P>0\^05). No complaint of side effects in the trial group was recorded. Conclusion Dibutyl phthalate is highly effective to demodicidosis without prominent adverse reactions.