摘要
本文采用大鼠和健康志愿者,对月见草油乳剂,以其中主要有效成分γ-亚麻酸为指标,进行了生物利用度研究。大鼠灌胃绝对生物利用度为73.21%;幽门静脉注射绝对生物利用度为89.91%;相对灌胃给予月见草油的相对生物利用度为176.6%.健康志愿者相对口服月见草油胶丸的相对生物利用度为173.5%. 实验结果说明,对于月见草油来说,乳剂是一种好剂型。
Reported in this article is the result of a study on the bioavailability of γ-linolenic acid from evening primrose oil and its emulsion in rats and men. The absolute bioavailability of γ-linolenic acid taken orally in the form of evening primrose oil emulsion is 73.21% in rats. The relative bioavailability of γ-linolenic acid when the oral administration of evening primrose oil emulsion is compared with that evening primrose oil (or its soft gelatin capsule), is 176.6% in rats(or 173.5% in men).
关键词
月见草油
乳剂
生物利用度
Evening primrose oiI
γ-Linolenic acid
Bioavailability
Emulsion
