胸腺肽联合乙肝疫苗治疗干扰素无应答的慢性乙型肝炎疗效观察

Clinical study on treatment of chronic hepatitis B with combination of thymosin and hepatitis B vaccine, which using interferon inefficacious.

观察胸腺肽联合乙肝疫苗对干扰素治疗后无应答的慢性乙型肝炎的疗效。分为胸腺肽加乙肝疫苗联合组４２例，胸腺肽组３０例，乙肝疫苗组２６例，护肝组２５例仅使用一般性保肝药物。疗程为６个月。结果ＨＢｅＡｇ／抗－ＨＢｅ转换率联合组４２．６％，胸腺肽组３０．０％，乙肝疫苗组１５．４％，联合组比后二者具有显著性差异（Ｐ＜０．０５）． ＨＢＶ－ＤＮＡ阴转率联合组 ５２．４％，胸腺肽组３６．７％，乙肝疫苗组 １９．２％，护肝组４．０％（Ｐ＜０．０１）。说明胸腺肽联合乙肝疫苗对干扰素治疗无应答的慢性乙型肝炎可取得较好疗效．

To observe the effect on chronic hepatitis B with combination of thymosin and hepatitis B Vaccine, wich using interferon inefficacious 42 cases of combining group (treated with thymosin and hepatitis B vaccine), 30 cases of thymosin group, 26 cases of hepatits B vaccine group and 25 cases of liver protecting group (treated only with common liver protectig medicine) were observed for 6 months. The result showed that The rate of exchang of HBsAg/Anti - HEe in combining group, in thymosin group and in hepatitis B vaccine group were 42. 6% , 30. 0% and 15.4% respectively. The combining group had significant difference compared with the latters. HBV-DNA negative rate in combining group was 52.4%, in thymosin group 36. 7%,in hepatitis B vaccine group 19.2%, in liver protecting group 4.0%(P<0.01). It indicated that combination of thymosin and hepatitis B vaccine to treat chronic hepatitis B standing Interferon could get satisfying effect.