口服或阴道应用米非司酮和米索前列醇对初孕妇女宫颈扩张的影响

THE EFFECTS OF ORAL OR VAGINAL MISOPROSTOL AND MIFEPRISTONE ON CERVICAL EXTENSION OF THE WOMEN WITH PRIMARY PREGNANCY

目的 :探讨米索前列醇和米非司酮对初孕妇宫颈扩张的最佳给药方式及剂量选择。方法 :通过 2 4 7例初孕妇人工流产 ,随机比较不同给药方式米非司酮和米索前列醇对宫颈的扩张作用、减少术中出血及减轻药物副反应等。结果 :各用药组对宫颈的扩张作用与对照组相比有显著差异 (P <0 .0 1) ;米索阴道放药组明显高于其他各组 (P <0 .0 1) ;阴道放置米索组术中副反应发生率明显低于其他各组 (P <0 .0 1) ;米索组出血量低于米非司酮组及对照组 ,给药途径与出血量多少无关 (P >0 .0 5 ) ;阴道给药组药物副反应发生率低于口服给药组 (P <0 .0 1)。结论 :阴道放置米索前列醇 4 0 0 μg不仅能扩张宫颈 ,而且能减轻药物副反应 ,值得人工流产前应用。

Objective:To determine the best means and dose of misoprostol and mifepristone on cervical dilatation of the women with primary pregnancy. Method:Among 247 cases of primary pergnancy who have undergone surgical abortion,the effects of mifepristone and misoprostol on cervical dilatation,operational bleeding and side effects in difference means of administering were randomly compared.Results:The different of cervical dilatation was significant between the treatment groups and control group ( P <0.01),among which the level of cervical dilatation in vaginal misoprostol group was significantly higher than those of other groups ( P <0.01);The rate of side-effects of surgical abortion in vaginal misoprostol group was lower than those of other groups ( P <0.01).The amount of bleeding in misoprostol groups was less than those of the mifepristone and control groups,and it had no relation with means of administering ( P >0.05).The rate of the side-effects of drugs in vaginal groups was lower than those of oral groups( P <0.01).Conclusions:400μg of vaginal misoprostol not only makes the cervical extension,but also reduces the side-effects of drug.It is worth applying before surgical abortion.