小儿醒胃液药效学研究

PHARMACODYNAMICS RESEARCH OF XIAO ER XING WEI YE

目的 :研究小儿醒胃液对食滞脾虚动物的作用机制。方法 :采用酚红定量法测定脾虚小鼠胃排空速度 ;用炭末法测定小肠的推进速度 ;用NaOH滴定法测定胃液的总酸度 ;用Anson_Mirshy改良法测定胃蛋白酶的活性。结果 :小儿醒胃液治疗组小鼠胃内酚红含量降低 ,小肠推进速度减慢 ;大鼠食量增加 ,胃液总酸度增加 ,胃蛋白酶活性增强 ,与模型组比较差异有显著性 (P <0 .0 5 )。结论 :小儿醒胃液是治疗儿童食滞脾虚证的良方。

Objective:To determine the mechanism of Xiao Er Xing wei Ye to animals with stagnation of food and in sufficiency of the spleen.Methods:The speed of gastric emptying of mice with spleen in sufficiency was measurd by phenol red quantitative analysis.The speed of small intestine moving forward was measured by charcoal powder mothed.The total acidity of gastric juice was measured by NaOH titration method.The activity of gastric proteinase was measured by improved Anson_Mirshy method.Results:The content of phenol red in mice's stomachs was reduced in Xiao Er Xing Wei Ye's groups.The speed of small intestine moving forward was slowed down.The capactity of rat was increased,the total acidity of gastric juice was raised,the activity of gastric proteinase was enhanced,and there was significant difference between the model group and Xiao Er Xing Wei Ye's group( P <0.05).Conclusions:Xiao Er Xing Wei Ye is a good prescription wihch can cure Children's in sufficiency of the spleen.