摘要
本实验观察了消炎痛、布洛芬、纳洛酮和吗啡治疗对清醒大鼠注射内毒素5 mg/kg 3 h血浆 CGRP 浓度的影响。结果表明,消炎痛、布洛芬和纳洛酮均明显地抑制休克时血浆CGRP 的升高,同时还明显地减轻休克时的肠道损伤;而吗啡治疗则无明显影响。本实验结果提示:体内炎症介质之一的前列腺素可能是引起内毒素休克时 CGRP 释放增加的重要内源性因子。
In the present study,we observed the effects of indomethacin,ibuprofen,nalo-xone and morphine on plasma CGRP concentration 3 h after endotoxin shock inconscious rats.The results showed that indomethacin,ibuprofen and naloxonesignificantly inhibited the elevation of plasma CGRP concentration as well as re-duced the lesion in the intestine during cndotoxin shock.However,morphinehad no significant effect.The data are consistent with our hypothesis that pro-staglandin,as one of the inflammatory mediatois which increase in shock,may be animportant endogenous factor for triggering the CGRP release during endotoxinshock.
出处
《生理学报》
CAS
CSCD
北大核心
1991年第4期410-413,共4页
Acta Physiologica Sinica
基金
国家青年自然科学基金
关键词
抗炎药
内毒素休克
CGRP
前列腺素
calcitonin gene-related peptide
antiinflammation
prostaglandins
opioid antagonists
endotoxin shock
