脑胶质瘤中p16蛋白、nm23蛋白及c-erbB-2蛋白的表达及其意义

Expression of p16 protein,nm23 protein and c-erbB-2 protein in the cerebral glioma and implication

目的 探讨p16蛋白、nm2 3蛋白及c erbB 2蛋白在脑胶质瘤发生、发展中的作用。方法 应用免疫组织化学技术检测 60例脑胶质瘤中 p16蛋白、nm2 3蛋白及c erbB 2蛋白的表达。结果 p16蛋白、nm2 3蛋白及c erbB 2蛋白在脑胶质瘤和正常脑组织中的阳性表达率分别为43 .3 %和 90 % (P <0 .0 5 ) ;3 6.7%和 80 % (P <0 .0 5 ) ;41.7%和 0 (P <0 .0 5 )。脑胶质瘤中 p16蛋白及nm2 3蛋白缺失率在死亡组和生存组分别为 73 .7%和 3 1.8% (P <0 .0 5 ) ;84.2 %和 3 6.3 %(P <0 .0 5 ) ;c erbB 2蛋白过度表达率在死亡组和生存组为 68.4%和 2 7.2 % (P <0 .0 5 )。结论 p16蛋白、nm2 3蛋白缺失和c erbB 2蛋白过度表达与脑胶质瘤发生、发展密切相关。

Objective To study the roles of p16 protein,nm23 protein and c erbB 2 protein in the tumorigenesis of the cerebral glioma.Methods The expression of p16 protein,nm23 protein and c erbB 2 protein was detected in 60 cases of cerebral glioma by using immunohistochemical technique.Results The positive expression rate of p16 protein,nm23 protein and c erbB 2 protein in cerebral glioma and normal brain tissues was 43.3% and 90% (P<0.05),36.7% and 80%,41.7% and 0 (P<0.05),respectively.Descended expression rate of p16 protein and nm23 protein in cerebral glioma with death group and survival group was 73.7% and 31.8% (P<0.05),84.2% and 36.3% (P<0.05),respectively.Excessive expression rate of c erbB 2 protein in cerebral glioma with death group and survival group was 68.4% and 27.2% (P<0.05).Conclusion Descended expression of p16 protein,nm23 protein and excessive expression of c erbB 2 protein may have close connection with the tumorigenesis of cerebral glioma.