老年性聋大鼠耳蜗COX活性的研究

The effects of the decreased activity of COX on rat cochlear with presbyacusis

目的 :探讨线粒体呼吸链细胞色素 C氧化酶 ( COX)活性异常在老年性聋发病中的作用机制。方法 :免疫组化法检测老年性聋大鼠耳蜗 COX活性。结果 :与正常对照组相比 ,实验组老年性聋大鼠耳蜗中 COX活性降低。结论 :耳蜗组织中

Objective:To study the effects of the abnormal activity of COX on rat cochlear with presbyacusis. Methods:The cytochrome C oxidase(COX) activity was measured by histochemical method in rat cochlear with presbyacusis. Results: The COX activity in the senescent rat cochlear was decreased in comparsion with normal control.Conclusion: The decrease of COX activity may play an important role in the pathogenesis of presbyacusis.