肺癌患者血清sIL-2R、IL-6和TNF-α水平的测定及临床意义

Detection and clinical evaluation of serum sIL-2R,IL-6 and TNF-α in patients with lung cancer

目的 :探讨血清 s IL- 2 R、IL- 6和 TNF- α的表达水平与肺癌诊断、疗效判定及预后的关系。方法 :双抗体夹心法测定肺癌患者血清中 s IL- 2 R、IL- 6和 TNF-α水平 ,并进行化疗前后对比。结果 :肺癌患者 s IL - 2 R、IL- 6和 TNF-α的生物活性均高于正常对照组 ,化疗后 s IL- 2 R、IL- 6和TNF-α水平较化疗前明显降低 ,差异有显性著 ( P<0 .0 1 )。结论 :s IL - 2 R、IL- 6和 TNF-α可作为肺癌诊断。

Objective:To study on the relationship between the serum levels of sIL 2R,IL 6 and TNF α and lung cancer diagnosis,therapeutic evaluation and prognosis.Methods:Serum sIL 2R,IL 6 and TNF α levels was detected by the ELISA,respedively,in lung cancer patients before chemotherapy,and compared with those of postchemotherapy.Results:The levels of sIL 2R,IL 6 and TNF α in patients with lung cancer were significantly higher than that of control.The levels of sIL 2R,IL 6 and TNF α was significantly decreased in patients with lung cancer after the chemotherapy.Conclusion:The biological activities of sIL 2R ,IL 6 and TNF α can be regarded as the supplementary indexes for diagnosis,therapeutic evaluation and prognosis in the patients with lung cancer.