免疫调节剂治疗外阴营养不良前后酶组织化学及局部免疫对比研究

Comparative study on enzymohistochemical and local immune changes before and after treatment with immuno modulator KBN in vulvar dystrophy

目的 :探讨外阴营养不良与酶组织化学、局部免疫的关系及经免疫调节剂 (克白宁 )治疗前后的变化。方法 :分别于治疗前后取局部病变组织进行 LDH、ACP、SDH、AKP、5′- N染色及Ig G、Ig A、Ig M、抗 C3 免疫荧光染色半定量测定。结果 :大部分标本 LDH、ACP值偏高 ,SDH、AKP、5′- N值偏低。TIC主要沉积在小血管壁、血管内皮及周围 ,基底膜亦可见 ,治疗前后 TIC沉积率及抗 C3 统计学处理差异有显著性。结论 :外阴营养不良与免疫异常 ,即病变组织 TIC沉积异常有关 ,酶组织化学亦有改变 ,经克白宁治疗可使

Objective:To explor enzymohistochemical and local immune changes in vulvar dystrophy and compair the changes inpathological tissue;befor and after teatmont with immunomodulafor,KBN. Mothods :Some local pathological tissues were taken before and after the treatment respectively.The tissues were stained by LDH,ACP,SDH,AKP and 5′ N and IgG, IgA, IgM, and anti C 3 then were determined by immunoscintigraphy semi quantitativly. Results:Values of LDH and ACP was higher but fuose of SDH AKP and 5′ N lower in most specimens.TIC sediments mainly lay on the small vasculars' wall, endothelium and their circumference as weel as their fundus. TIC deposition rate and anti C 3 before and after treatment were significantly diffetent in statistics. Conclution: Vulvar dystrophy is related to the abmormality of TIC deposition in pathological tissues and related to enzymohistochemical change.Therapy with KBN can improve the TIC deposition.