硫酸奈替米星的合成工艺改进

An Improved Synthetic Process of Netilmicin Sulfate

改进了硫酸奈替米星合成工艺中的关键步骤 ,将三乙酰基西索米星中活性官能团先行保护后 ,改用硼氢化钠代替昂贵进口品氰基硼氢化钠 ,并采用一锅合成法制得成品 ,简化了工艺 ,降低了原材料成本 ,成品的收率和质量也有明显的提高。

Netilmicin sulfate was synthesized from sisomicin via one pot process. Sodium borohydride was used instead of sodium cyanoborohydride. This process is simpler, and the yield and quality of product is higher.