盐酸尼卡地平凝胶家兔在体透皮吸收研究

Study on Percutaneous Absorption of Nicardipine Hydrochloride Gel through Rabbit Skin in vivo

进行了盐酸尼卡地平凝胶的家兔在体透皮吸收研究 ,评价月桂氮酮对其透皮吸收的促进作用。通过测定家兔皮肤给药后不同时间的血药浓度值 ,得到了血药 -时间曲线 ,经拟合获得了透皮吸收的主要药动学参数。结果表明加入月桂氮酮后尼卡地平的峰浓 (Cmax)、血药浓度曲线下面积 (AUC0～ 2 4h)和平均滞留时间 (MRT)三个参数均显著增加 (P<0 .0 0 0 1) ,而达峰时间 (Tmax)和时滞 (Tlag)两个参数无显著性改变 (P>0 .0 5 )。

The percutaneous absorption of nicardipine hydrochloride gel through rabbit skin in vivo was investigated and the promotion effect of laurocapram on skin penetration was evaluated. The main pharmacokinetic parameters showed that laurocapram could significantly increase C max , AUC 0~24 h and MRT(P<0.0001), but had no effects on the T max and T lag (P>0.05).