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湖南地区汉族系统性红斑狼疮患者HLA-DM多态性研究 被引量:2

HLA-DM POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN HAN NATIONALITY PEOPLE OF HUNAN
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摘要 目的 :探讨湖南地区系统性红斑狼疮患者的遗传易感性基因。方法 :运用PCR -SSO方法分析SLE患者和正常人群中HLADM基因的多态性。结果 :正常人群和SLE人群组中 ,DMA 0 10 1及DMB 0 10 1频率占主要地主 ,DMA 0 10 4和DMB 0 10 4为罕见基因 ,两组之间无显著性差异。结论 :湖南地区SLE患者中未发现HLADM易感基因。 Objective:To determine the susceptible genetic factors related to systemic lupus erythematosus in Hunan.Methods:DMA and DMB typing was performed in SLE patients and healthy controls,using PCR-SSO(sequence specific oligonucleotide probes) method.Results:The frequencies of DMA*0101 and DMB*0101 were the predominant alleles in healthy people of Han nationality as well as in SLE patients. DMA*0104 and DMB*0104 were rare alleles.Conclusions: HLA-DM gene has no susceptibility to SLE in Han nationality people of Hunan .
出处 《中国现代医学杂志》 CAS CSCD 2001年第11期6-7,共2页 China Journal of Modern Medicine
基金 湖南省科委资助课题 ( 96 -10 1-14 )
关键词 系统性红斑狼疮 HLA-DM 多态性 lupus erythematosus, systemic HLA-DM
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