CD44V9和nm23基因蛋白在胃癌中的表达及其临床意义

CLINICAL SIGNIFICANCE OF CD44V9 AND NM23 GENE PROTEIN EXPRESSION IN GASTRIC CARCINOMAS

目的 :探讨胃癌组织中CD44V9和nm2 3的表达、相互关系及其临床意义。方法 :应用免疫组化SABC法对 6 0例胃癌中CD44V9和nm2 3表达进行检测。结果 :胃癌组织中CD44V9和nm2 3的阳性表达率分别为75 %和 5 5 %;CD44V9阳性胃癌中nm2 3阳性表达率 (4 2 .2 %)明显低于CD44V9阴性胃癌 (93.3%) (P <0 .0 1)。CD44V9阳性表达与胃癌Lauren分型、浸润深度及淋巴结转移有关 (P <0 .0 5 ) ,nm2 3表达与胃癌淋巴结转移有关 (P <0 .0 5 )。结论 :CD44V9和nm2 3在胃癌中表达呈明显负相关 ,二者有可能作为临床上预测胃癌侵袭转移潜能的指标。

Objective:To investigate the clinical significance and correlation of CD44V9 and nm23 expressions in gastric carcinoma.Methods:Expression of CD44V9 and nm23 proteins in 60 cases with gastric carcinoma was detected by SABC immunohistochemical technique.Results:The total positive rate of expression of CD44V9 and nm23 proteins in gastric carcinoma was 75% and 55%,respectively.In CD44V9 positive cases,the positive rate of nm23(42.2%) was significantly lower than that in CD44V9 negative cases (93.3%)(P<0.001).The expression of CD44V9 in gastric carcinoma was markedly correlated with histological type,invasion depth and lymph node metastasis(P<0.01),while the expression of nm23 was significantly associated with lymph node metastasis (P<0.05).Conclusions:The expression of CD44V9 protein is negative related to nm23 protein in gastric carcinoma.They are significant markers for predicting the potential invasion and metastasis of gastric carcinoma.