单纯形法在微生物生长动力学和能学参数估算中的应用

The Application of Simplex Method to the Estimation of Kinetic and Energetic Parameters of Microbial Growth

本文基于作者所导出的用于描述微生物分批和连续培养的数学模型,就单纯形法在微生物生长动力学和能学参数估算中的应用进行研究。根据模型的特点,提出确定目标函数及单纯形初始值的方法,并以大肠杆菌单罐连续培养为例介绍了估算的全过程。

Based on the mathematical models derived by the author for descri-bing both batch microbial cultivation and continuous one, the applica-tion of simplex method to the estimation of K_s、μ_(max)、Y_(x/s)^(max) and m_s isinvestigated. Methods of determination of objective function and initialvalue of simplex method as well as the introduction of the whole processof estimation with single tank continuous culture of E.coli as anexample is presented.