硒对红细胞膜抗氧化作用的探讨

STUDIES ON THE ANTI-PEROXIDATION OF SELENIUM ON ERYTHROCYTE MEMBRANES

本文以红细胞膜在体外与超氧阴离子自由基(由邻苯三酚自氧化产生)反应所致氧化损伤作为实验模型,研究了Na_2SeO_3,NaHSeO_3,Na_2SeO_2和SeO_2等硒化合物对红细胞膜的作用。结果表明,Na_2SeO_3有抗氧化作用。表现为膜蛋白交联作用显著减小,脂质过氧化物(膜荧光物质)含量下降。本文还就硒抗氧化作用的机理作了讨论。

The treatment of human erythrocyte membranes with superoxide anion (O_2^-) produced by pyrogallic acid, pH8.4, caused peroxidative damages to cell membranes, such as increase of fluorescent substance on membranes, formation of high molecular polymers (HMP) due to membrane protein cross-linking. However, these were almost not induced after adding a certain amount of Na_2SeO_3. It is suggested the anti-peroxidation effect of Na_2SeO_3 on erythrocyte membranes