血红蛋白A_2现象发生机制的研究——“红细胞HbA_2”为HbA_2与HbA的结合产物

MECHANISM OF HEMOGLOBIN A_2 PHENOMENON "ERYTHROCYTE HbA_2" IS A BINDING PRODUCT OF HbA_2 AND HbA

为了弄清血红蛋白A_2现象的发生机制,我们对“红细胞HbA_2”的化学组成进行了分析。“红细胞HbA_2”的双向电泳结果表明,它含有两种血红蛋白成分:一种相当于HbA,另一种很可能是溶血液HbA_2。其单向二次电泳结果也证明,它是由溶血液HbA_2和HbA所组成。结果初步说明,盘红细胞中HbA_2可能与HbA结合存在。两者可能有相互作用,也许这是产生血红蛋白A_2现象的原因。

1. Chemical composition of erythrocyte HbA_2 was analyzed in order to clarify the mechanism of hemoglobin A_2 phenomenon. The paper reports the hemoglobin composition of erythrocyte HbA_2.2. The results of two-dimensional electrophoresis showed that erythrocyte HbA_2 contains two Hb components: one corresponds to HbA and the other most probably is hemolysate HbA_2.3. The results of one-dimensional re-electrophoresis showed definitly that erythrocyte HbA_2 is composed of hemolysate HbA_2 and HbA.4. Tentative conclusion: HbA_2 may be combined with HbA in erythrocyte, i. e. there is probably interaction between the two hemoglobins. This is perhaps the possible cause of hemoglobin A_2 phenomenon.