氨氯地平产生的兔股动脉舒张部分由NO介导

The Relaxation of Rabbit Femoral Artery Induced by Amlodipine is Partialy Dependent on Nitric Oxide

目的 研究氨氯地平舒张周围血管的作用是否与激活一氧化氮合酶 (NOS)有关。方法 利用家兔股动脉恒流灌注模型 ,观察股动脉内灌注有效浓度的氨氯地平后灌注压的变化及NOS抑制剂L NAME对其作用的影响。结果 氨氯地平缓慢平稳降低周围血管阻力 ,NOS抑制剂L NAME能部分阻断这种作用。结论 氨氯地平产生的周围血管舒张作用部分通过刺激NO生成而实现。

Objective To determine whether vasorelaxation induced by amlodipine depend on eNOS activation. Method A constant perfusion model of rabbit femoral artery was used to observe the changes of perfusion pressure before and after intra arterial infusing 10 -3 mol·L -1 amlodipine 0 5 ml and the effect of NOS inhibitor L NAME on this action. Result Relaxation of rabbit femoral artery bed induced by amlodipine was partialy inhibited by NOS inhibitor L NAME. Conclusion Vasorelaxation induced by amlodipine is mediated partialy through eNOS activation.