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Castleman′s病与滤泡性淋巴瘤的免疫组化研究 被引量:1

IMMUNOHISTOCHEMISTRY ANALYSIS IN CASTLEMAN DISEASE AND FOLLICULAR LYMPHOMA
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摘要 目的 :探讨 Castleman′s病与滤泡性淋巴瘤的鉴别诊断方法。方法 :应用免疫组化方法对 19例Castlem an′s病与 2 2例滤泡型淋巴瘤进行 bcl- 2肿瘤基因蛋白和κ、λ表达测定。结果 :19例 Castleman′s病不论何种亚型 17例生发中心细胞 bcl- 2阴性 ,κ、λ呈多克隆表达。 2 2例滤泡性淋巴瘤中 19例 bcl- 2呈阳性 ,3例 bcl- 2阴性 ,κ、λ呈单克隆表达。表达 bcl- 2、κ和λ,X检验 Castleman′s病与滤泡性淋巴瘤两者在 bcl- 2、κ和λ表达方面有显著性差异 (P<0 .0 1)。结论 :bcl- 2结合κ、λ对 Castlem Objective:To study a method to distinguish Castleman′s disease(CD) from follicular lymphoma(FL).Methods:A immunohistochemical staining method was used to detect the expression of bcl 2 oncogene protein,Kappa and Lambda in 19 cases of CDs and 22 cases of FLs.Results:No matter which type CD bcl 2 was negtive in 17 of 19 cases and ,expression of Kappa and Lambda was polyclonal.But bcl 2 was positive in 19 of 22 cases FLs and expressioin of Kappa and Lambda was monoclonal.There is a significant diference between CD and FL on expression of bcl 2?Kappa and Lambda.Conclusion:bcl 2?Kappa and Lambda may play an important role in the differential diagnsis of CD and FL.
出处 《白血病.淋巴瘤》 CAS 2001年第5期288-289,共2页 Journal of Leukemia & Lymphoma
关键词 Castleman's病 滤泡性淋巴瘤 bcl-2癌基因蛋白 鉴别诊断 Castleman′s disease Follicular lymphoma bcl 2 Differential diagnosis
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