利培酮与氯丙嗪对精神分裂症认知功能的影响

A comparison of cognitive function in schizophrenia treated with risperidone and chlorpromazine

目的 :比较利培酮和氯丙嗪对首发精神分裂症患者认知功能的影响。 方法 :将符合入组标准的首发精神分裂症 62例随机分为利培酮组与氯丙嗪组 ,分别进行 8周系统治疗 ,用阳性与阴性症状量表 ( PANSS)、韦氏成人智力量表 ( WAIS- RC)、数字划销试验 ( CT)和临床记忆量表 ( CMS)进行检查 ,评估其疗效和对认知功能的影响。 结果 :脱落 3例 ,5 9例患者在 8周治疗后 PANSS总分明显下降 ,但两组之间差异无显著性。利培酮组的 WAIS- RC、CT、CMS总分均明显高于氯丙嗪组 ,差异有显著性。 结论

Objective:To compare the effects of risperidone and chlorpromazine on cognitive function in the first onset schizophrenic patients. Method:62 patients with first onset schizophrenia were randomly divided into risperidone group and chlorpromazine group for 8 weeks.The therapeutic response and cognitive function were assessed by the positive and negative symptoms scale (PANSS),Wechsler adult intelligence scale (WAIS),the cancellation test (CT),and the clinical memory scale (CMS). Results:The total score of PANSS was significantly decreased after treatment with risperidone or chlorpromazine.But no significant differences were found between two groups.The total score of WAIS,CT and CMS were significantly higher in risperidone group than in chlorpromazine group. Conclusion:The study suggests that the effects of risperidone on cognitive function in first onset schizophrenia are better than that of chlorpromazine.