不同人群风疹病毒感染及免疫状况研究

Study on the Immunity and Infection Status in Different Population

目的 了解人群风疹免疫状况 ,为风疹疫苗纳入计划免疫提供科学依据。 方法 采用酶联免疫吸附试验(ELISA) ,检测深圳地区不同对象人群风疹特异性抗体IgG或IgM。 结果 一般人群R -IgG阳性率 6 8 0 9% ,其中 <30岁组人群抗体阳性率为 6 5 2 2 % ,≥ 30岁组人群抗体阳性率为 80 2 7% ,其差异有显著性意义 ( χ2 =18 78,P <0 0 5 )。孕妇人群R -IgM阳性率 0 18% ,R -IgG阳性率 75 6 1%。 32 8例RFIs病例中R -IgM阳性率 9 45 %。观察 16 8例风疹疫苗免疫效果 ,免后抗体阳性率 10 0 % ,GMRT 199 70 ,免疫成功率为 95 83%。 结论 低龄儿童和青年少年风疹免疫水平较低 ,是风疹免疫的主要对象 ,而育龄妇女是风疹免疫的重点对象 ,国产风疹疫苗具有良好的免疫原性 。

Objective To understand the rubella immune status of population in order to provide science reference for the strategies on prevention and control. Methods ELISA was used to test rubella special IgG or IgM antibody of object. Result In cases of 1～40 years old age groups;the positive rate of R-IgG antibody was 68.09%. In pregnant woman group the positive rates of R-IgM antibody was 0.18%, the positive rates of R-IgG antibody was 75.61%. 328 RFIs cases were tested,the rates of R-IgM antibody was 9.45%.To observe the effect of rebella vaccines,168 case were tested. the positive rates of R-IgG antibody before immunity former was 80.36% and after was 100%. The immunity succeed rate was 95.83%.Conclusion The immune level of Less than 30 years old was lower, they were easiest to the attack by rubella virus,so they were the primary immune object of rubella vaccines The women of procreation age were important immunity object of rubella vaccines.The rubella vaccines mede by china get a better immune efficacy.